Gives off irritating or toxic fumes (or gases) in a fire. Fumaric acid None identified 2. : 203-743-0 Molecular Weight: 116.07 Chemical Formula: HOOCCH=CHCOOH . - Find MSDS or SDS, a COA, data sheets and more information. Precautionary Statements: P280 Wear protective gloves/protective clothing/eye protection/face protection. Carboxylic acids donate hydrogen ions if a base is present to accept them. Agricultural chemicals from maleic anhydride include pesticides, herbicides and growth regulators. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. More information about Classification and Labelling is available in the Regulations section of ECHA website. The hazard assessment of this substance is triggered by the effects observed in a chronic repeated dose toxicity study. Incompatible Materials Bases, Strong oxidizing agents, Reducing Agent Hazardous Decomposition ProductsCarbon monoxide (CO), Carbon dioxide (CO2) Hazardous Polymerization Hazardous polymerization does not occur. Gives off irritating or toxic fumes (or gases) in a fire. Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and of substances in closed systems with minimal release. REACH registered substance data was upgraded on 9th November. 0000001405 00000 n 29 0 obj<> endobj * Fumaric Acid may damage the kidneys. Other: Consult professionals if Fumaric Acid need to be handled under some special conditions. FUMARIC ACID FOR SYNTHESIS is not on the REACH Candidate List FUMARIC ACID FOR SYNTHESIS is not on the REACH Annex XIV List 15.1.2. 0000001775 00000 n msds fumaric acid This section is based on three sources for information (harmonised classification and labelling (CLH), REACH registrations and CLP notifications). 0000009127 00000 n Hazardous Substances - Art. inside a watch) or with very low concentrations considered not to pose risks to human health or the environment. Synonyms: 2-Butenedioic acid; Boletic acid CAS No. %%EOF We provide Fumaric Acid safety data sheets view and download at Echemi.com. it is recommended that all dust control equipment and material transport systems involved are engineered to prevent conditions contributing to dust explosions. Fumaric acid CAS-No. GHS product identifier Other means of identification Product type Section 1. Contact with eyes: May cause eye irritation. FUMARIC ACID: ICSC: 1173 (E)-2-Butenedioic acid trans-1,2-Ethylenedicarboxylic acid Allomaleic acid Boletic acid: June 2011: CAS #: 110-17-8 EC Number: 203-743-0 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. The use information is displayed per substance life cycle stage (consumer use, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). Prolonged contact with eyes or skin may cause irritation. 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, C&L Inventory, Pre-Registration process, CAD - Chemical Agents Directive, Art. 0000001584 00000 n 0000005970 00000 n Inhalation: Inhalation of dust may cause respiratory tract irritation. 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Substances of very high concern identification, Recommendation for the Authorisation List, Getting started with EU chemicals legislation, Classification of substances and mixtures, Harmonised classification and labelling (CLH). Chronic: Not expected to be a chronic hazard. The CLP Regulation uses the UN Global Harmonised System (GHS) and European Union Specific Hazard Statements (EUH). in case of consumer and professional uses). 110-17-8 Eye Irrit. 7.2. 215–540–4, is covered by three harmonisations: 005–011–00–4; 005–011–01–1 and 005–011–02–9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. ,w���J:�&�pB(�hPʋ �*�I���np4�%M���S���Kv��-X��_�tHnp��#(d;���r�.� National regulations Germany Reference to AwSV : Water hazard class (WGK) 1, low hazard to water (Classification according to AwSV; ID No. 5.2 SPECIFIC HAZARDS FIRE AND EXPLOSION HAZARD: Possibility of dust explosion. FUMARIC ACID: ICSC: 1173 (E)-2-Butenedioic acid trans-1,2-Ethylenedicarboxylic acid Allomaleic acid Boletic acid: June 2011: CAS #: 110-17-8 EC Number: 203-743-0 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance causes serious eye irritation. The CAS number is the substance numerical identifier assigned by the Chemical Abstracts Service, a division of the American Chemical Society, to substances registered in the CAS registry database. Ingestion: No hazard expected in normal industrial use. xref For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet. Other release to the environment of this substance is likely to occur from: indoor use (e.g. 0000004719 00000 n The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. If at least one company has indicated that the substance classification is affected by impurities or additives, this will be indicated by an informative sentence. This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). Some substance identifiers may have been claimed confidential, or may not have been provided, and therefore not be displayed. The quality and correctness of the information submitted to ECHA remains the responsibility of the data submitter. <]>> 0000003524 00000 n Public (risk management) activities co-ordination table. Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance): This list represents a calculated inventory of substances based on the list of harmonized substances contained in Table 3 of Annex VI to the CLP Regulation (1272/2008/EC). HAZARDS IDENTIFICATION Hazards Not Otherwise Classified: No information available Signal Word: WARNING OSHA Classification: Hazard Category: Hazard Statement: Eye Damage/Irritation 2A Causes serious eye irritation. This acid is an irritant and skin sensitizer. P264 Wash hands thoroughly after handling. This directive requires employers to ensure proper signage is posted in areas where hazards cannot be avoided or reduced. Fumaric Acid Trans-butenedioic Acid, trans-1,2-Ethylenedicarboxylic acid 2-Butenedioic acid Allomaleic acid Boletic acid Donitic acid Lichenic acid Solid, White Crystalline. Fumaric acid-1,4-13 C 2,2,3-d 2 2 Product Results | Match Criteria: Product Name This information is only displayed if the substance is well–defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. Exposure to moist air or water. Other Classifications: WHMIS (Canada): CLASS D-2A: Material causing other toxic effects (VERY TOXIC). : 682001: Relevant identified uses of the substance or mixture: Identified: Laboratory chemical uses: R&D: Uses advised against: HPC Standards GmbH Am Wieseneck 7 04451 Cunnersdorf Deutschland Tel. Fumaric acid-2,3-d2 | C4H4O4 | CID 12201062 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. 0000001188 00000 n (USCG, 1999) Guidance on safe use - recommendations by substance registrant on the proper use of the substance in various situations. * Breathing Fumaric Acid can irritate the nose and throat causing coughing and wheezing. It is the responsibility of the substance manufacturers and importers to consult official publications, e.g. Isolate from incompatible substances. Welcome to PubChem! Protect against physical damage. SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. 110-17-8 Fumaric acid 99% 203-743-0 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes. Product identifier Product name Fumaric acid Product number FF23617 CAS number 110-17-8 EC number 203-743-0 1.2. Release to the environment of this substance can occur from industrial use: formulation of mixtures, in processing aids at industrial sites and in the production of articles. 7.1. Hazard classification & labelling Hazard classification and labelling. Potential Health Effects Eye: Causes moderate eye irritation. trans-1,2-Ethylenedicarboxylic. We apologise for the inconvenience in the meantime. Information on precautionary measures and the safe use is submitted by the registrant of a substance and the registrant is solely responsible for its accuracy and completeness. Substances indicated, in 2009, as being intended to be registered by at least one company in the EEA. It is possible that a harmonisation is introduced through an amendment to the CLP Regulation. In such a case, the victim should be allowed to stand in a well-ventilated area. The date of the last update corresponds to the publication date of the InfoCard and not necessarily to the date in which the update occurred in the source data. Other release to the environment of this substance is likely to occur from: outdoor use and indoor use as processing aid. SAFETY DATA SHEET: FUMARIC ACID FUMARIC ACID F765.32 INTEGRA Chemical Company 24 Hour Emergency Response: CHEMTREC 800-424-9300 (Outside USA 703-527-3887) 1216 6th Ave N Kent WA 98032 Phone: 253-479-7000 HO2CCH:CHCO2H 116.07 They react in this way with all bases, both organic (for example, the amines) and inorganic. Identification::: Fumaric Acid SAFETY DATA SHEET Product code:Not available. Substances which have been registered and can be placed on the EEA market by those companies with a valid registration. Precautionary Statements: P280 Wear protective gloves/protective clothing/eye protection/face protection. The examples provided are generic examples and may not apply to the specific substance you are viewing. Fumaric Acid GHS SDS, MSDS Sheet, Material Safety Data Sheet. S 28A After contact with skin, wash immediately with plenty of water More information about the EC Inventory can be found here. 10.3 Possibility of hazardous reactions. (USCG, 1999) FUMARIC ACID is a carboxylic acid. Prevent dust build-up by providing adequate ventilation. FUMARIC ACID is a carboxylic acid. Please upgrade your Internet Explorer to a newer version. If available, additional information on classification and labelling (C&L) is derived from REACH registration dossiers submitted by industry. SAFETY DATA SHEET Fumaric Acid Issued: 01/06/2015 Page 2 Signal Word: Warning Hazard Statements: H319 Causes serious eye irritation. REACH regulation aims to improve the protection of human health and the environment from the risks that can be posed by chemicals. 0000003770 00000 n Eliminate Any Ignition Until The Area Is Determinded To Be Free From Explosion Or Fire Hazards. Substances may have impurities and additives that lead to different classifications. 203-743-0 Index-No. 0000000016 00000 n C&L Inventory . However, it may be dangerous if inhaled as it may cause respiratory irritation. Fumaric acid is sometimes found in processed foods such as smoked meats. 0000004027 00000 n The EC or list number is the primary substance identifier used by ECHA. Hazardous Reactions None under normal processing. Welcome to PubChem! SECTION 6 : Accidental release measures Personal precautions, protective equipment and emergency procedures: Wear protective equipment. Bioaccumulative potential FUMARIC ACID CRS(110-17-8) Log Pow 0,46 at 20°C 12.4. While the harmonized list covers many hazardous substances, other ones not listed may also meet the classification criteria in accordance with the CLP. Commission Regulation (EU) No 2015/830 of 28 May 2015. InfoCards are updated when new information is available. Special Hazards of Combustion Products: Irritating smoke containing maleic anhydride may form in fire. Note that this list is not exhaustive. Fumaric acid: Catalog No. Its E number is E297. Fumaric Acid | Structure, Uses, Hazards, & Properties | - Genuine chemistry - The ultimate resource for Chemistry. When heated to decomposition it emits irritating fumes and acrid smoke [Lewis, 3rd ed., 1993, p. 790]. The ‘Hazard classification’ and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information. Biocidal Products Committee opinions on active substance approval, National authorisation and mutual recognition, Understanding the Waste Framework Directive, Tools to prepare and submit SCIP notifications, List of substances subject to the POPs Regulation, Draft recommendation for inclusion in the Authorisation List and consultation, Submitted restrictions under consideration, Harmonised classification and labelling targeted consultations, Consultations on ECHA Executive Director’s requests, PACT - Public Activities Coordination Tool, Information on Candidate List substances in articles, Candidate List of substances of very high concern for Authorisation, Registry of restriction intentions until outcome, Registry of SVHC intentions until outcome, Table of harmonised entries in Annex VI to CLP, Occupational exposure limits - Activity list, Harmonised classification and labelling (RAC), Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment, Guidance on the safe use of the substance, PACT - Public activities Co-ordination Tool, CAD - Chemical Agents Directive,Art. Warning! machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use. Fumaric acid has been used as a food acidulant since 1946. This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing. It is approved for use as a food additive in the EU, USA and Australia and New Zealand. Gives off irritating or toxic fumes (or gases) in a fire. The precautionary measures and guidance on safe use are as submitted to ECHA by registrants under the REACH Regulation. OTHER HAZARDS FIRE AND EXPLOSION HAZARD: May form combustible dust concentrations in air. SARA 311/312 Hazards Acute Health Hazard Massachusetts Right To Know Components Maleic acid CAS-No. Skin: Causes mild skin irritation. 7.4. Occupational exposure limit (OEL) values are derived within two legal frameworks that form an integral part of the EU’s mechanism for protecting the health of workers. Fumaric acid is an organic compound with the formula HO 2 CCH=CHCO 2 H. A white solid, fumaric acid occurs widely in nature. Product Name: FUMARIC ACID Revision Date: 03.06.2019 Page 3 of 6 5. CAS 110-17-8, EC Number 203-743-0, chemical formula HOOCCHCHCOOH. Also referred to as the Plastics Implementation Measure (PIM), this Regulation provides the Union List of monomers and other substances authorized in the manufacture of food contact plastics. Skin : Wash Thoroughly With Soap And Water. Ingestion: No hazard expected in normal industrial use. What Is Fumaric Acid E297? This site is not fully supported in Internet Explorer 7 (and earlier versions). Please note: Precautionary measures and guidance on safe use concern the use and handling of the specific substance as such, not of the presence of the substance in other articles or mixtures. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment). Hazards Identification. Fumaric acid is stable although it is subject to degradation by both aerobic and anaerobic microorganisms. Statements 2.3 Other hazards This substance/mixture contains no components considered to be either persistent, bioaccumulative and Fumaric acid and its sodium salts damage the kidney, digestivesystem and liver, and cause flushing. Slightly hazardous in case of skin contact (irritant, permeator), of 2 Emergency First Aid: Get Medical Assistance For All Cases Of Overexposure. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. 8.5.1.1 Succinic, fumaric, and malic acid. Fumaric acid is used in the making of wheat tortillas as a food preservative and as the acid in leavening. These notifications can be provided by manufacturers, importers and downstream users. Structure, properties, spectra, suppliers and links for: Fumaric acid, 110-17-8. P264 Wash hands thoroughly after handling. Fumaric acid According to Regulation (EC) No 1907/2006, Annex II, as amended. Harmonisation is based on the substance’s physical, toxicological and eco-toxicological hazard assessment. Keep Fumaric Acid in a tightly closed container, stored in a cool, dry, ventilated area. Fumaric acid | C4H4O4 | CID 444972 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. 6(6), Reg. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment. This information is only displayed if the substance is well-defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. When information is available in all sources, the first two are displayed as a priority. For readability purpose, only non-confidential use descriptors occurring in more than 5% of total occurrences are displayed. : HY-W015883 CAS No. SLIGHTDust explosion possible if in powder or granular form, mixed with air.FUMARIC ACID is a carboxylic acid. Details of dossier compliance checks and testing proposal evaluation. Fumaric acid is a stable and harmless compound by contact with the skin or eyes. Fumaric acid for synthesis. There's a medical application for … This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, for intermediate use only. RTECS # LS9625000 ... Synonyms. Composition / Information on Ingredients Common Name Fumaric Acid Synonym(s) 2-Butenedioic acid Formula C 4 H 4 O 4 CAS Number 110-17-8 COMPONENT CAS NUMBER CONCENTRATION 1.1 Product identifier. The CLP Regulation ensures that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through classification and labelling of chemicals. 7.3. HAZARDS IDENTIFICATION 2.1 GHS classification PHYSICAL HAZARDS Not classified HEALTH HAZARDS Not classified ENVIRONMENTAL HAZARDS Not classified 2.2 GHS label elements, including precautionary statements Pictograms or hazard symbols None Union List of Authorized Substances: Annex I, Plastics Food Contact Regulation 10/2011/EU, as amended by Regulation 2020/1245/EU, 3 September 2020, EU. Possibility of dust explosion. Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates). : 110-17-8 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, manufacture of substances. Supplemental Hazard none Page 1 of 7 Fumaric Acid CAS No 110-17-8 MATERIAL SAFETY DATA SHEET SDS/MSDS . Hazardous overview: Fumaric Acid is Slightly hazardous in case of inhalation, skin contact, ingestion or eye contact. Philip Lutze, in Distillation, 2014. Maleic acid or cis-butenedioic acid is an organic compound that is a dicarboxylic acid, a molecule with two carboxyl groups. Fumaric acid: Catalog No. 0000008487 00000 n There is no data available. FUMARIC ACID CRS(110-17-8) LC50 fishes 1 245 mg/l LC50-96 Hour - fish (48h) EC50 Daphnia 1 204 - 220 mg/l EC50 - 48 Hour - Daphnia magna 12.2. However, substance notifications in the InfoCard are aggregated independently of the impurities and additives. Succinic, fumaric, and malic acid are four-carbon diacids that are produced via similar biochemical paths [7].These acids can be used as building blocks for the production of large commodity chemicals, such as 1,4-butanediol, tetra-hydrofuran, hydroxybutyrolacetone [7], or succinates [27,28]. Fumaric acid LD50 Dermal Rabbit>20000 mg/kg-LD50 Oral Rat6800 mg/kg-Fumaric acid Eyes - Moderate irritantRabbit-24 hours 100 mg-Skin - Mild irritantRabbit-24 hours 500 mg-Sensitization There is no data available. 110-16-7 Revision Date 2007-03-01 Pennsylvania Right To Know Components Maleic acid CAS-No. fumaric acid 110-17-8 > 99 Section 4 - FIRST AID MEASURES SWALLOWED If swallowed do NOT induce vomiting. 0 The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. Precautionary statements - describe recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product or improper storage or handling of a hazardous product. Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. Show this safety data sheet to the doctor in attendance. 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Previous consultations on ECHA’s Executive Director Requests to the Committees, Applications for authorisation consultations, Harmonised classification and labelling consultations, ECHA Executive Director’s requests related to the CLH process, Consultation on potential candidates for substitution, Consultation on derogation to the exclusion criteria, ECHA's Executive Director Requests to the Committees, Consultation on a draft recommendation for amendment of Authorisation List entries, Consultations in the authorisation process, Occupational exposure limits - Call for comments and evidence, Occupational exposure limits - Previous calls for comments and evidence, Occupational exposure limits – Consultations on OEL recommendation, Derogations for the protection of cultural heritage, ECHA's current activities on restrictions, ECHA's completed activities on restriction, Information on Candidate List substances in articles table, Information from the Existing Substances Regulation (ESR), PBT/vPvB assessments under the previous EU chemicals legislation, Adopted opinions and previous consultations on applications for authorisation, Adopted opinions on restriction proposals, Mapping exercise – Plastic additives initiative, Occupational exposure limits substance evaluations, List of substances subject to POPs Regulation, Small and Medium-sized Enterprises (SMEs), Practical examples of chemical safety reports. 0000006655 00000 n This substance is used in the following areas: scientific research and development, building & construction work and agriculture, forestry and fishing. Hazards Identification. +49 34291 3372-36 Fax. Furthermore, some substances can be found in an article, but with unlikely exposure (e.g. Substances Rendering Goods Ineligible for EU Ecolabel, Art. Section 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of eye contact (irritant), of ingestion.